Metabolism of the antianxiety drug buspirone in human subjects". Digoxin may decrease the cardiotoxic activities of Azathioprine. Pentoxifylline leads to the inhibition of thromboxane and increase of prostacyclin synthesis. Digoxin may decrease the cardiotoxic activities of Temsirolimus. Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyryl-cholinesterase in AD patients before and after treatment with different AChE inhibitors. Paliperidone: (Major) Avoid coadministration of tamoxifen with paliperidone due to an increased risk of QT prolongation.